Neuropathic pain, a chronic pain condition following nerve damage and degeneration,
involves aberrant excitability in the dorsal horn of the spinal cord. A growing body of …

Extracellular nucleotides play pivotal roles in the regulation of neuronal and glial functions in
the nervous system through P2X receptors (P2XRs) and P2Y receptors (P2YRs). A growing …

Pain is an essential modality of sensation in the body. Purinergic signaling plays an
important role in nociceptive pain transmission, under both physiological and …

Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge.
The molecular and cellular mechanisms underlying its development and maintenance are …

Many pathological processes within the central nervous system are mediated by complex
interactions between neurons and resident glial cells. In the case of painful peripheral …

Emerging evidence indicates that microglia play a critical role in the pathogenesis of
neuropathic pain, a debilitating chronic pain condition that can occur after peripheral nerve …

A growing body of evidence indicates that extracellular nucleotides play important roles in
the regulation of neuronal and glial functions in the nervous system through P2 …

Neuropathic pain that typically develops when peripheral nerves are damaged through
surgery, bone compression in cancer, diabetes, or infection is a major factor causing …

We have learned various data on the role of purinoceptors (P2X4, P2X7, P2Y6 and P2Y12)
expressed in spinal microglia and several factors that presumably activate microglia in …

Microglia are key cellular mediators of plasticity in the spinal cord that drives the
development and maintenance of pain hypersensitivity following peripheral nerve damage …