Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a …

C Criscuolo, E Chartampila, SD Ginsberg… - eneuro, 2024 - eneuro.org
Brain-derived neurotrophic factor (BDNF) is important in the development and maintenance
of neurons and their plasticity. Hippocampal BDNF has been implicated in Alzheimer's …

[HTML][HTML] Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimer's disease neuropathology in …

C Criscuolo, E Chartampila, SD Ginsberg… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The neurotrophin brain-derived neurotrophic factor (BDNF) is important in development and
maintenance of neurons and their plasticity. Hippocampal BDNF has been implicated …

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice

GJ Burbach, R Hellweg, CA Haas… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a versatile neurotrophic factor that has been
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …

Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology

NA Castello, KN Green, FM LaFerla - 2012 - journals.plos.org
Brain-derived neurotrophic factor (BDNF) is a neurotrophin critically involved in cell survival,
synaptic plasticity, and memory. BDNF has recently garnered significant attention as a …

Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease

S Peng, DJ Garzon, M Marchese, W Klein… - Journal of …, 2009 - Soc Neuroscience
Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in …

DJ Garzon, M Fahnestock - Journal of Neuroscience, 2007 - Soc Neuroscience
Alzheimer's disease (AD) is a senile dementia characterized by amyloid plaques,
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …

Hippocampal BDNF expression in a tau transgenic mouse model

S Burnouf, K Belarbi, L Troquier… - Current Alzheimer …, 2012 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular
accumulation of amyloid deposits and intracellular neurofibrillary tangles (NFT) composed of …

Brain-derived neurotrophic factor in Alzheimer's disease: risk, mechanisms, and therapy

JH Song, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

[图书][B] Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?

M Fahnestock, D Garzon, RMD Holsinger, B Michalski - 2002 - Springer
Brain derived neurotrophic factor (BDNF) promotes cholinergic neuron function and survival.
In Alzheimer's disease, BDNF mRNA and protein are decreased in basal forebrain …

Conditional depletion of hippocampal brain-derived neurotrophic factor exacerbates neuropathology in a mouse model of Alzheimer's disease

DJ Braun, S Kalinin, DL Feinstein - ASN neuro, 2017 - journals.sagepub.com
Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes to the
evolution of neuroinflammation and neurodegeneration in a variety of conditions and …