The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study
AJ Dicker, M Lonergan, HR Keir, AH Smith… - The Lancet …, 2021 - thelancet.com
Background Infection is a key component of bronchiectasis pathophysiology.
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …
Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients
Background Bronchiectasis is accompanied by chronic bronchial infection that may drive
disease progression. However, the evidence base for antibiotic therapy is limited. DNA …
disease progression. However, the evidence base for antibiotic therapy is limited. DNA …
[HTML][HTML] The microbiome in bronchiectasis
H Richardson, AJ Dicker, H Barclay… - European Respiratory …, 2019 - Eur Respiratory Soc
Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …
Inflammatory molecular endotypes in bronchiectasis: a European multicenter cohort study
H Choi, S Ryu, HR Keir, YH Giam… - American Journal of …, 2023 - atsjournals.org
Rationale: Although inflammation and infection are key disease drivers in bronchiectasis,
few studies have integrated host inflammatory and microbiome data to guide precision …
few studies have integrated host inflammatory and microbiome data to guide precision …
Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation
MM Tunney, GG Einarsson, L Wei, M Drain… - American journal of …, 2013 - atsjournals.org
Rationale: Characterization of bacterial populations in infectious respiratory diseases will
provide improved understanding of the relationship between the lung microbiota, disease …
provide improved understanding of the relationship between the lung microbiota, disease …
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis
Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of
the bronchi and is characterised by chronic infection and associated inflammation. The …
the bronchi and is characterised by chronic infection and associated inflammation. The …
A novel microbiota stratification system predicts future exacerbations in bronchiectasis
Rationale: Although airway microbiota composition correlates with clinical measures in non–
cystic fibrosis bronchiectasis, these data are unlikely to provide useful prognostic information …
cystic fibrosis bronchiectasis, these data are unlikely to provide useful prognostic information …
Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition
Rationale Despite the potentially important roles for infection in adult non-cystic fibrosis (CF)
bronchiectasis disease progression, the bacterial species present in the lower airways of …
bronchiectasis disease progression, the bacterial species present in the lower airways of …
Endotyping chronic obstructive pulmonary disease, bronchiectasis, and the “chronic obstructive pulmonary disease–bronchiectasis association”
JTJ Huang, E Cant, HR Keir, AK Barton… - American Journal of …, 2022 - atsjournals.org
Rationale: Bronchiectasis and chronic obstructive pulmonary disease (COPD) are two
disease entities with overlapped clinical features, and codiagnosis frequently occurs (termed …
disease entities with overlapped clinical features, and codiagnosis frequently occurs (termed …
Clinical phenotypes in adult patients with bronchiectasis
S Aliberti, S Lonni, S Dore… - European …, 2016 - Eur Respiratory Soc
Bronchiectasis is a heterogeneous disease. This study aimed at identifying discrete groups
of patients with different clinical and biological characteristics and long-term outcomes. This …
of patients with different clinical and biological characteristics and long-term outcomes. This …
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