Aims: Concurrent use of ethanol and nicotine (tobacco) is often seen in human beings. In
previous animal experiments, we have demonstrated that nicotinic acetylcholine receptors …

Ethanol and nicotine are the most abused drugs, and it is well known that co-abuse of
ethanol and nicotine is frequent in human beings. We have previously obtained results …

It has been suggested that the mesolimbic dopamine activating and the reinforcing
properties of ethanol involve activation of central nicotinic acetylcholine receptors. To test …

It was previously demonstrated that the central nicotinic acetylcholine receptor antagonist
mecamylamine perfused in the ventral tegmental area (VTA) counteracts the elevation of …

The mesocorticolimbic dopamine system is believed to be involved in mediating the positive
reinforcing effects of drugs of abuse, including ethanol. The nicotinic acetylcholine receptor …

It has been suggested that ethanol exerts its mesolimbic dopamine activating effects and its
reinforcing effects via interaction with central nicotinic acetylcholine receptors, thus providing …

Ethanol-induced elevations of accumbal dopamine levels have been linked to the
reinforcing properties of the drug. However, it has not yet been demonstrated where the …

Ethanol-induced accumbal dopamine elevations have been linked to ethanol consumption.
It is unclear, however, where along the mesolimbic dopamine system this effect is initiated …

Ethanol shares with all major dependence producing drugs the ability to activate brain
mesocorticolimbic dopamine neurons, an important part of the brain reward systems. This …

Background: Alcoholism is associated with a higher incidence of smoking. The mesolimbic
dopaminergic pathway is believed to play an important role in the reinforcing effects of both …