Brain cancers and neurodegenerative diseases are on the rise, treatments for central
nervous system (CNS) diseases remain limited. Despite the significant advancement in drug …

Brain, the center of the nervous system in all vertebrate, plays the most vital role in every
function of human body. However, many neurodegenerative diseases, cancer and infections …

Being the most delicate organ of the body, the brain is protected against potentially toxic
substances by the blood-brain barrier (BBB), which restricts the entry of most …

Introduction: The development of therapeutics for central nervous system (CNS) disorders is
still considered a challenging area in drug development due to insufficient translocation …

The blood–brain barrier presents a significant hurdle in CNS drug development. Blood-to-
brain delivery by effectively crossing this barrier allows therapeutics to reach a large area of …

Drug delivery into the brain has for long been a huge challenge as the blood–brain barrier
(BBB) offers great resistance to entry of foreign substances (with drugs inclusive) into the …

Introduction: The blood-brain barrier (BBB) selectively impedes the transportation of drug
molecules into the brain, which makes the drug delivery and targeting of brain tumors very …

This Theme Issue of Advanced Drug Delivery Reviews is devoted to strategies for brain drug
delivery and targeting. The scientific foundation of brain drug targeting is rooted in the …

Drug delivery to brain is still a challenging task due to the presence of the blood–brain
barrier (BBB), a very restrictive barrier mainly composed of tightly sealed endothelial cells …

The administration of drugs to the CNS has become a difficult task because several barriers
in the brain, ie the blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier must be …