Drug delivery to the brain: recent advances and unmet challenges
Brain cancers and neurodegenerative diseases are on the rise, treatments for central
nervous system (CNS) diseases remain limited. Despite the significant advancement in drug …
nervous system (CNS) diseases remain limited. Despite the significant advancement in drug …
Current approaches for drug delivery to central nervous system
S Hossain, T Akaike… - Current Drug …, 2010 - ingentaconnect.com
Brain, the center of the nervous system in all vertebrate, plays the most vital role in every
function of human body. However, many neurodegenerative diseases, cancer and infections …
function of human body. However, many neurodegenerative diseases, cancer and infections …
Getting into the brain: approaches to enhance brain drug delivery
MM Patel, BR Goyal, SV Bhadada, JS Bhatt, AF Amin - CNS drugs, 2009 - Springer
Being the most delicate organ of the body, the brain is protected against potentially toxic
substances by the blood-brain barrier (BBB), which restricts the entry of most …
substances by the blood-brain barrier (BBB), which restricts the entry of most …
Selective drug delivery approaches to lesioned brain through blood brain barrier disruption
ZS Al-Ahmady - Expert opinion on drug delivery, 2018 - Taylor & Francis
Introduction: The development of therapeutics for central nervous system (CNS) disorders is
still considered a challenging area in drug development due to insufficient translocation …
still considered a challenging area in drug development due to insufficient translocation …
Enhanced brain drug delivery: safely crossing the blood–brain barrier
PJ Gaillard, CC Visser, CCM Appeldoorn… - Drug Discovery Today …, 2012 - Elsevier
The blood–brain barrier presents a significant hurdle in CNS drug development. Blood-to-
brain delivery by effectively crossing this barrier allows therapeutics to reach a large area of …
brain delivery by effectively crossing this barrier allows therapeutics to reach a large area of …
Multi-disciplinary approach for drug and gene delivery systems to the brain
NB Ndemazie, A Inkoom, EF Morfaw, T Smith… - AAPS …, 2022 - Springer
Drug delivery into the brain has for long been a huge challenge as the blood–brain barrier
(BBB) offers great resistance to entry of foreign substances (with drugs inclusive) into the …
(BBB) offers great resistance to entry of foreign substances (with drugs inclusive) into the …
Drug delivery and targeting to brain tumors: Considerations for crossing the blood-brain barrier
Introduction: The blood-brain barrier (BBB) selectively impedes the transportation of drug
molecules into the brain, which makes the drug delivery and targeting of brain tumors very …
molecules into the brain, which makes the drug delivery and targeting of brain tumors very …
[PDF][PDF] Preface: Overview of brain drug delivery
WM Pardridge - Advanced Drug Delivery Reviews, 1995 - researchgate.net
This Theme Issue of Advanced Drug Delivery Reviews is devoted to strategies for brain drug
delivery and targeting. The scientific foundation of brain drug targeting is rooted in the …
delivery and targeting. The scientific foundation of brain drug targeting is rooted in the …
A Review on novel techniques for drug delivery to the brain
AK Parashar, RK Nema - Current Research in Pharmaceutical …, 2012 - crpsonline.com
Drug delivery to brain is still a challenging task due to the presence of the blood–brain
barrier (BBB), a very restrictive barrier mainly composed of tightly sealed endothelial cells …
barrier (BBB), a very restrictive barrier mainly composed of tightly sealed endothelial cells …
Current approaches and prospective drug targeting to brain
R Khatoon, MA Alam, PK Sharma - Journal of Drug Delivery Science and …, 2021 - Elsevier
The administration of drugs to the CNS has become a difficult task because several barriers
in the brain, ie the blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier must be …
in the brain, ie the blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier must be …