Modulation of ionic channels and insulin secretion by drugs and hormones in pancreatic beta cells
Pancreatic beta cells, unique cells that secrete insulin in response to an increase in glucose
levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion …
levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion …
Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling
M Gil-Rivera, RM Medina-Gali, J Martínez-Pinna… - International review of …, 2021 - Elsevier
The human and mouse islet of Langerhans is an endocrine organ composed of five different
cells types; insulin-secreting β-cells, glucagon-producing α-cells, somatostatin-producing δ …
cells types; insulin-secreting β-cells, glucagon-producing α-cells, somatostatin-producing δ …
[HTML][HTML] Beta-cell ion channels and their role in regulating insulin secretion
B Thompson, LS Satin - Comprehensive physiology, 2021 - ncbi.nlm.nih.gov
Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …
Potassium channels of the insulin‐secreting B cell
P Petit, MM Loubatières‐Mariani - Fundamental & clinical …, 1992 - Wiley Online Library
Ionic and electrical events play a central role in the stimulus‐secretion coupling of the
pancreatic B cell. Potassium permeability is critically involved in the regulation of B cell …
pancreatic B cell. Potassium permeability is critically involved in the regulation of B cell …
Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic β-cells
HQ Dou, YF Xu, JP Sun, S Shang… - … of Physiology-Cell …, 2012 - journals.physiology.org
While glucose-stimulated insulin secretion depends on Ca2+ influx through voltage-gated
Ca2+ channels in the cell membrane of the pancreatic β-cell, there is also ample evidence …
Ca2+ channels in the cell membrane of the pancreatic β-cell, there is also ample evidence …
[HTML][HTML] ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on …
Closure of ATP-regulated K+ channels (K ATP channels) plays a central role in glucose-
stimulated insulin secretion in beta cells. K ATP channels are also highly expressed in …
stimulated insulin secretion in beta cells. K ATP channels are also highly expressed in …
[HTML][HTML] Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals
PM Heister, T Powell, A Galione - Scientific reports, 2021 - nature.com
Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of
stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be …
stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be …
The role of ion channels in insulin secretion
AE Boyd III - Journal of cellular biochemistry, 1992 - Wiley Online Library
Ion channels in beta cells regulate electrical and secretory activity in response to metabolic,
pharmacologic, or neural signals by controlling the permeability to K+ and Ca2+. The ATP …
pharmacologic, or neural signals by controlling the permeability to K+ and Ca2+. The ATP …
Thapsigargin-sensitive cationic current leads to membrane depolarization, calcium entry, and insulin secretion in rat pancreatic β-cells
R Cruz-Cruz, A Salgado… - American Journal …, 2005 - journals.physiology.org
Glucose-induced insulin secretion by pancreatic β-cells depends on membrane
depolarization and [Ca2+] i increase. We correlated voltage-and current-clamp …
depolarization and [Ca2+] i increase. We correlated voltage-and current-clamp …
Glucose-incretin interaction revisited
H Ishii, Y Sato, M Takei, S Nishio, M Komatsu - Endocrine journal, 2011 - jstage.jst.go.jp
Pancreatic beta cell dysfunction is pivotal to the development of diabetes, and restoration of
insulin action is of primary importance. Here, we present a review of the mechanism of …
insulin action is of primary importance. Here, we present a review of the mechanism of …
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