Pancreatic beta cells, unique cells that secrete insulin in response to an increase in glucose
levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion …

The human and mouse islet of Langerhans is an endocrine organ composed of five different
cells types; insulin-secreting β-cells, glucagon-producing α-cells, somatostatin-producing δ …

Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …

Ionic and electrical events play a central role in the stimulus‐secretion coupling of the
pancreatic B cell. Potassium permeability is critically involved in the regulation of B cell …

While glucose-stimulated insulin secretion depends on Ca2+ influx through voltage-gated
Ca2+ channels in the cell membrane of the pancreatic β-cell, there is also ample evidence …

Closure of ATP-regulated K+ channels (K ATP channels) plays a central role in glucose-
stimulated insulin secretion in beta cells. K ATP channels are also highly expressed in …

Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of
stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be …

Ion channels in beta cells regulate electrical and secretory activity in response to metabolic,
pharmacologic, or neural signals by controlling the permeability to K+ and Ca2+. The ATP …

Glucose-induced insulin secretion by pancreatic β-cells depends on membrane
depolarization and [Ca2+] i increase. We correlated voltage-and current-clamp …

Pancreatic beta cell dysfunction is pivotal to the development of diabetes, and restoration of
insulin action is of primary importance. Here, we present a review of the mechanism of …