Diet-induced extinctions in the gut microbiota compound over generations

ED Sonnenburg, SA Smits, M Tikhonov… - Nature, 2016 - nature.com
The gut is home to trillions of microorganisms that have fundamental roles in many aspects
of human biology, including immune function and metabolism,. The reduced diversity of the …

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

LE Parton, CP Ye, R Coppari, PJ Enriori, B Choi… - Nature, 2007 - nature.com
A subset of neurons in the brain, known as 'glucose-excited'neurons, depolarize and
increase their firing rate in response to increases in extracellular glucose. Similar to insulin …

Profiling cellular diversity in sponges informs animal cell type and nervous system evolution

JM Musser, KJ Schippers, M Nickel, G Mizzon… - Science, 2021 - science.org
The evolutionary origin of metazoan cell types such as neurons and muscles is not known.
Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Plasticity-driven individualization of olfactory coding in mushroom body output neurons

T Hige, Y Aso, GM Rubin, GC Turner - Nature, 2015 - nature.com
Although all sensory circuits ascend to higher brain areas where stimuli are represented in
sparse, stimulus-specific activity patterns, relatively little is known about sensory coding on …

Universality of human microbial dynamics

A Bashan, TE Gibson, J Friedman, VJ Carey, ST Weiss… - Nature, 2016 - nature.com
Human-associated microbial communities have a crucial role in determining our health and
well-being,, and this has led to the continuing development of microbiome-based therapies …

State-dependent decoupling of sensory and motor circuits underlies behavioral flexibility in Drosophila

JM Ache, S Namiki, A Lee, K Branson, GM Card - Nature neuroscience, 2019 - nature.com
An approaching predator and self-motion toward an object can generate similar looming
patterns on the retina, but these situations demand different rapid responses. How central …

A holidic medium for Drosophila melanogaster

MDW Piper, E Blanc, R Leitão-Gonçalves, M Yang… - Nature …, 2014 - nature.com
A critical requirement for research using model organisms is a well-defined and consistent
diet. There is currently no complete chemically defined (holidic) diet available for Drosophila …

Predicting a human gut microbiota's response to diet in gnotobiotic mice

JJ Faith, NP McNulty, FE Rey, JI Gordon - Science, 2011 - science.org
The interrelationships between our diets and the structure and operations of our gut
microbial communities are poorly understood. A model community of 10 sequenced human …

Gut anatomical properties and microbial functional assembly promote lignocellulose deconstruction and colony subsistence of a wood-feeding beetle

JA Ceja-Navarro, U Karaoz, M Bill, Z Hao… - Nature …, 2019 - nature.com
Beneficial microbial associations enhance the fitness of most living organisms, and wood-
feeding insects offer some of the most striking examples of this. Odontotaenius disjunctus is …