Biological Target. SMARCA2 and SMARCA4 Summary. The SMARCA subgroup of genes
belong to the SWI1/SNF1 family that provide instructions for making chromatin remodeling …

Abstract The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4
is frequently mutated in cancer and inactivation results in a cellular dependence on its …

SMARCA2 is an attractive synthetic lethality target for human cancers with SMARCA4
deficiency. Herein, we report the design, synthesis, and biological evaluation of selective …

SWI/SNF complexes play an important role in controlling gene expression by remodeling
chromatin. SMARCA2 (BRM) and SMARCA4 (BRG1) are the core subunits of the SWI/SNF …

Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy
solve an apparently intractable selectivity challenge with SMARCA4 by utilising the …

Disease Area. Cancer Biological Target. SMARCA2 Summary. The field of targeted protein
degradation promoted by small molecules has been intensively studied. Bifunctional …

Introduction The multi-subunit SWI/SNF chromatin remodeling complex is a key epigenetic
regulator for many cellular processes, and several subunits are found to be mutated in …

Background► SWItch/Sucrose Non-Fermentable (SWI/SNF) complexes play an important
role in controlling gene expression by remodeling chromatin. 1► SWI/SNF Related, Matrix …

Introduction SMARCA2 and SMARCA4 are subunits of the SWI/SNF complex which is a
chromatin remodeling complex and a key epigenetic regulator that facilitates gene …

Bromodomains (BRDs) are epigenetic protein–protein interaction modules that are involved
in gene transcription. Most often, multiple bromodomains are present in nuclear complexes …