[HTML][HTML] Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

DY Zhang, T Tu, MR Younis, KS Zhu, H Liu, S Lei… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Acute kidney injury (AKI) is associated with aberrant generation of oxidative
species and inflammation, leading to high mortality of in-hospitalized patients. Although N …

Novel gold-platinum nanoparticles serve as broad-spectrum antioxidants for attenuating ischemia reperfusion injury of the kidney

S Feng, Y Qu, B Chu, X Chen, Z Yang, P Li, P Wang… - Kidney International, 2022 - Elsevier
Kidney ischemia reperfusion injury (IRI) is a common and inevitable pathological condition
in routine urological practices, especially during transplantation. Severe kidney IRI may …

Engineered nanodrug targeting oxidative stress for treatment of acute kidney injury

L Li, Y Shen, Z Tang, Y Yang, Z Fu, D Ni, X Cai - Exploration, 2023 - Wiley Online Library
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in renal
function, and is associated with a high risk of death. Many pathological changes happen in …

Natural metal polyphenol nanozyme: free radical scavenging and antioxidation for the treatment of acute kidney injury

H Yuan, F Wang, Z Wang, D Gu, W Huang… - ACS Materials …, 2023 - ACS Publications
Acute kidney injury (AKI) is a severe renal dysfunction syndrome associated with high
morbidity and mortality. Excessive production of reactive oxygen/nitrogen species (RONS) is …

Tailoring Oxidation Responsiveness of Gold Nanoclusters via Ligand Engineering for Imaging Acute Kidney Injury

S Li, N Yang, Q Ma, S Li, S Tong, J Luo… - Analytical …, 2023 - ACS Publications
Gold nanoclusters (AuNCs) have shown great promise for in vivo imaging because of their
definable structure, tunable photoluminescence (PL), and desired renal clearance …

Engineering antioxidative cascade metal-phenolic nanozymes for alleviating oxidative stress during extracorporeal blood purification

Z Wei, G Peng, Y Zhao, S Chen, R Wang, H Mao… - ACS …, 2022 - ACS Publications
Oxidative stress is a compelling risk factor in chronic kidney diseases and is further
aggravated for individuals during extracorporeal blood purification, ultimately leading to …

Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress

HS Choi, AP Mathew, S Uthaman, A Vasukutty… - Journal of …, 2022 - Springer
Background The reactive oxygen species (ROS) and inflammation, a critical contributor to
tissue damage, is well-known to be associated with various disease. The kidney is …

Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury

DY Zhang, H Liu, T He, MR Younis, T Tu, C Yang… - Small, 2021 - Wiley Online Library
Acute kidney injury (AKI) is frequently triggered by abundant reactive oxygen/nitrogen
species (RONS) and leads to high morbidity and mortality in clinic. Unfortunately, the current …

pH‐Activatable Pre‐Nanozyme Mediated H2S Delivery for Endo‐Exogenous Regulation of Oxidative Stress in Acute Kidney Injury

W Jiang, X Hou, Y Qi, Z Wang, Y Liu, XJ Gao… - Advanced …, 2024 - Wiley Online Library
Oxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic
cause of acute kidney injury (AKI). Development of an effective antioxidation system to …

Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation

Z Xu, Y Zhu, M Xie, K Liu, L Cai, H Wang, D Li… - Journal of …, 2023 - Springer
Background Iron sulfide nanomaterials have been successfully employed as therapeutic
agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due …