Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi.
Chronic kidney disease (CKD) and hypertension (HTN) are two major public health …

Abstract Purpose of Review In chronic kidney disease (CKD), plasma uric acid levels are
increased because of the decrease in glomerular filtration rate. However, in addition to CKD …

The relationship between hyperuricemia, gout, and renal disease has been investigated for
several years. From the beginning, kidney disease has been considered a complication of …

Hyperuricemia (elevated serum uric acid) is prevalent, and an important mediator of gout, an
increasingly common condition. In addition, hyperuricemia is associated with metabolic …

Results: The causes for hyperuricemia in overproducers may be either exogenous or
endogenous. CKD has become a global public health problem because of its high …

Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric
acid. It is affected by genetic predisposition related to uric acid transporters and by visceral …

Observational studies have shown that asymptomatic hyperuricemia is associated with
increased risks of hypertension, chronic kidney disease (CKD), end-stage renal disease …

Epidemiological studies show that hyperuricemia independently predicts the development of
chronic kidney disease (CKD) in individuals with normal kidney function both in the general …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

Hyperuricemia is seen when kidney function declines. Whether elevated uric acid (UA)
levels play a role in the initiation and progression of kidney disease is a subject of a great …