Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that
participate in many physiological functions. Receptors result from the assembly of five …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand gated ion channels, which
are found at the neuromuscular junction and in the central and peripheral nervous systems …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Neuronal nicotinic acetylcholine receptors (nAChRs) are widespread, diverse ion channels
involved in synaptic signaling, addiction, and disease. Despite their importance, the …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

The nicotinic acetylcholine receptor (nAChR) is the prototype of the cys-loop family of ligand-
gated ion channels (LGIC) that also includes GABAA, GABAC, glycine, 5-HT3 receptors, and …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …