Carboxylesterases-detoxifying enzymes and targets for drug therapy
PM Potter, RM Wadkins - Current medicinal chemistry, 2006 - ingentaconnect.com
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics
MR Redinbo, PM Potter - Drug discovery today, 2005 - Elsevier
Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …
agents has grown rapidly in recent years, and we are now able to begin to apply this …
Carboxylesterase inhibitors: an update
LW Zou, Q Jin, DD Wang, QK Qian… - Current Medicinal …, 2018 - ingentaconnect.com
Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
Modifications of human carboxylesterase for improved prodrug activation
JM Hatfield, M Wierdl, RM Wadkins… - Expert opinion on drug …, 2008 - Taylor & Francis
Background: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the
hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in …
hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in …
Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human
ET Williams, JA Bacon, DM Bender, JJ Lowinger… - Drug metabolism and …, 2011 - ASPET
The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …
[HTML][HTML] Human carboxylesterases: a comprehensive review
D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
Recent progress in the discovery of natural inhibitors against human carboxylesterases
DD Wang, LW Zou, Q Jin, J Hou, GB Ge, L Yang - Fitoterapia, 2017 - Elsevier
Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …
Planarity and constraint of the carbonyl groups in 1, 2-diones are determinants for selective inhibition of human carboxylesterase 1
JL Hyatt, RM Wadkins, L Tsurkan… - Journal of medicinal …, 2007 - ACS Publications
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …
The impact of carboxylesterases in drug metabolism and pharmacokinetics
L Di - Current drug metabolism, 2019 - ingentaconnect.com
Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
Human carboxylesterases: an update on CES1, CES2 and CES3
SP Sanghani, PC Sanghani, MA Schiel… - Protein and peptide …, 2009 - ingentaconnect.com
Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …
variety of drug esters, amides, carbamates and similar structures. There are five …