Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Background: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the
hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in …

The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …