Although successful remission has been achieved when cancer is diagnosed and treated
during its earliest stages of development, a tumor that has established neovascularization …

Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about
the role vascular cells play in the tumor microenvironment. In vitro models that mimic in vivo …

Cells cultured within a three-dimensional (3D) in vitro environment have the ability to
acquire phenotypes and respond to stimuli analogous to in vivo biological systems. This …

Tumour microenvironment greatly influences the development and metastasis of cancer
progression. The development of three dimensional (3D) culture models which mimic that …

Tumor angiogenesis is controlled by the integrated action of physicochemical and biological
cues; however, the individual contributions of these cues are not well understood. We have …

The induction of angiogenesis and the promotion of tumor growth and invasiveness are
processes critical to metastasis, and are dependent on reciprocal interactions between …

The plasticity of the tumour microenvironment is a key contributor to cancer development
and progression. Here, we present a bioengineered breast tumour angiogenesis model …

Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …

A major paradigm shift in cancer research is the emergence of multidisciplinary approaches
to investigate complex cell behaviors, to elucidate regulatory mechanisms and to identify …

Introduction• History of tissue engineering• Physiological and structural aspects of 2D versus
3D culture in cancer research• State of the art of 3D culture systems in cancer research• New …