The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …

The tumor microenvironment is a key factor in the progression and metastasis of cancer, the
complexity of which is not reproducible using two-dimensional (2D) culture models. While …

Tumor-induced angiogenesis is a key event for neoplastic progression. In vitro assays are
important for identification of potential angiogenic agents and rapid sceening for …

Clinically usable tissue-engineered constructs are currently limited due to their inability of
forming microvascular networks necessary for adequate cellular oxygen and nutrient supply …

Emerging evidence shows that endothelial cells are not only the building blocks of vascular
networks that enable oxygen and nutrient delivery throughout a tissue but also serve as a …

A prerequisite for successful tissue engineering is adequate vascularization that would allow
tissue engineering constructs to survive and grow. Angiogenic growth factors, alone and in …

Neoangiogenesis is crucial for solid tumor growth and invasion, as the vasculature provides
metabolic support and access to the circulation. Current antiangiogenic therapies have been …

An important issue in tissue engineering is the vascularisation of the implanted construct,
which often takes several weeks. In vivo, the growth factors VEGF and FGF2 show a …

The establishment of a vascular network within tumours is a key step in the progression
towards an aggressive, metastatic state, with poor prognosis. We have developed a novel in …

Recent studies indicate that continuous administration improves the antitumoral efficacy of
angiogenesis inhibitors, as compared with intermittent dosing, suggesting a potential role of …