The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a
series of specialized epithelia that are regenerated by specific populations of stem cells. To …

Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly
replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of …

Intestinal Stem Cells in Mammals and Drosophila Page 1 Cell Stem Cell Minireview Intestinal
Stem Cells in Mammals and Drosophila Andreu Casali1,2 and Eduard Batlle1,3,* 1Institute for …

Drosophila has long been an excellent model organism for studying stem cell biology.
Notably, studies of Drosophila's germline stem cells have been instrumental in developing …

Epithelial stem cells are regulated through a complex interplay of signals from diffusible
ligands, cellular interactions, and attachment to the extracellular matrix. The development of …

Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

Stem cell division is essential for tissue integrity during growth, aging, and pathogenic
assaults. Adult gastrointestinal tract encounters numerous stimulations, and impaired tissue …

Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic
stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate …

Adult tissue homeostasis requires a tight balance between the removal of old or damaged
cells and the production of new ones. Such processes are usually driven by dedicated stem …

Stem cell‐mediated tissue repair is a promising approach for many diseases. Mammalian
intestine is an actively regenerating tissue such that epithelial cells are constantly shedding …