Intestinal inflammation is widely recognized as a pivotal player in health and disease.
Defined cytologically as the infiltration of leukocytes in the lamina propria layer of the …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

The past three decades have seen an unremitting quest to identify and understand
gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their …

Current views of the identity, distribution, and regulation of small intestinal epithelial stem
cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in …

The conventional model of intestinal epithelial architecture describes a unidirectional tissue
organizational hierarchy with stem cells situated at the crypt base and daughter cells …

The epithelial cell lining of the gastrointestinal tract is the most rapidly proliferating tissue in
the body. The constant state of renewal of differentiated epithelial cells is sustained by a …

The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed
with extensive adaptability. The more traditional view of a hierarchical organization of the gut …

The epithelium of the adult mammalian intestine is in a constant dialog with its underlying
mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation …

The study of adult stem cell populations provides insight into the mechanisms that regulate
tissue maintenance in normal physiology and many disease states. With an impressive rate …

Drosophila adult midgut intestinal stem cells (ISCs) maintain tissue homeostasis by
producing progeny that replace dying enterocytes and enteroendocrine cells. ISCs adjust …