Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of
small-sized stem cell populations that continuously generate new progeny to replace lost …

Advances in our understanding of stem cells in the gastrointestinal tract include the
identification of molecular markers of stem and early progenitor cells in the small intestine …

Tissues that undergo self-renewal such as the skin, the haematopoeitic system and the
intestine are all maintained and renewed by a small group of multipotent stem cells. The …

A dynamic pool of undifferentiated somatic stem cells proliferate and differentiate to replace
dead or dying mature cell types and maintain the integrity and function of adult tissues …

The Drosophila and mammalian digestive systems bear striking similarities in genetic
control and cellular composition, and the Drosophila midgut has emerged as an amenable …

Gastrointestinal stem cells are shown to be pluripotential and to give rise to all cell lineages
in the epithelium. After damage, gut stem cells produce reparative cell lineages that produce …

Recent seminal studies have rapidly advanced the understanding of intestinal epithelial
stem cell (IESC) biology in murine models. However, the lack of techniques suitable for …

Among the endodermal tissues of adult mammals, the gastrointestinal (GI) epithelium
exhibits the highest turnover rate. As the ingested food moves along the GI tract, gastric acid …

The cellular origin of digestive cancers has been a long-standing question in the cancer
field. Mouse models have identified long-lived stem cells in most organ systems, including …

We have sequenced 36,641 expressed sequence tags from laser capture microdissected
adult mouse gastric and small intestinal epithelial progenitors, obtaining 4031 and 3324 …