Vertebrate and invertebrate digestive systems show extensive similarities in their
development, cellular makeup and genetic control. The Drosophila midgut is typical …

An enormous body of knowledge about the biology of stem cells and their role in
development, tissue homeostasis and cancer formation has been gained in the last 20 …

Systemic and stem cell niche-emanating cytokines and growth factors can promote
regeneration, through mitosis. High mitosis, however, predisposes for all types of cancer …

Background & Aims: Epithelial stem cells in the stomach are responsible for constant
renewal of the epithelium through generation of multiple gastric cell lineages that populate …

Coordination of stem cell activity with inflammatory responses is critical for regeneration and
homeostasis of barrier epithelia. The temporal sequence of cell interactions during injury …

The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and
maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To …

Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs).
Following damage or stress the intestinal epithelium produces ligands that activate the …

The intestinal epithelium contains a rapidly proliferating and perpetually differentiating
epithelium. The principal functional unit of the small intestine is the crypt–villus axis. The …

The mechanism by which a cell commits and proceeds to full differentiation is currently
unknown. However, certain homeobox transcription factors are likely to be involved …

Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that
they can maintain proliferative output while simultaneously protecting themselves from DNA …