For centuries, clinicians have been taught to examine and classify patients on the basis of
topographical lesion and the underlying pathology. In most clinical specialities, such an …

Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

As we approach the new millennium, it is clear that we are on the brink of a major change in
clinical pain management. We are poised to move from a treatment paradigm that has been …

Classification of neuropathic pain according to etiology or localization has clear limitations.
The discovery of specific molecular and cellular events following experimental nerve injury …

Neuropathic pain is part of the neurological disease spectrum and may be an expression of
severe medical pathology. Painful neuropathies have multiple disguises and may to a …

Peripheral neuropathic pain, that clinical pain syndrome associated with lesions to the
peripheral nervous system, is characterized by positive and negative symptoms. Positive …

There have been considerable advances in our understanding of the pathophysiology of
neuropathic pain. There is still a lack of consensus about the optimal therapeutic strategy of …

It is self evident that the recent explosive growth in our understanding of the molecular,
cellular and system's mechanisms responsible for nociception and pain has important …

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …