Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges

M Diab, A Azmi, R Mohammad… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Despite many efforts to improve the outcome of pancreatic ductal
adenocarcinoma (PDAC), its prognosis remains poor, which is mostly related to late …

[PDF][PDF] Targeted therapy for pancreatic cancer: Lessons learned and future opportunities

AG Thomas, N Awasthi - 2021 - scholarworks.iupui.edu
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis
because of its aggressive character, late-stage diagnosis, and resistance against systemic …

[HTML][HTML] Smarter drugs emerging in pancreatic cancer therapy

A Kleger, L Perkhofer, T Seufferlein - Annals of Oncology, 2014 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer death in
the Western world. Owing to a lack of specific symptoms and no accessible precursor …

Pancreatic cancer: progress in systemic therapy

L Perkhofer, TJ Ettrich, T Seufferlein - Gastrointestinal Tumors, 2015 - karger.com
Background: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-
related deaths in the Western world. Due to lack of specific symptoms and no accessible …

Changing the course of pancreatic cancer–Focus on recent translational advances

M Javle, T Golan, A Maitra - Cancer treatment reviews, 2016 - Elsevier
In the past decade, insightful preclinical research has led to important breakthroughs in our
understanding of pancreatic cancer. Even though the vast majority of pancreatic cancers are …

Targeted therapies in pancreatic cancer: promises and failures

M Barati Bagherabad, F Afzaljavan… - Journal of Cellular …, 2019 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an incidence rate nearly equal to its mortality
rate. The poor prognosis of the disease can be explained by the absence of effective …

Two decades of research toward the treatment of locally advanced and metastatic pancreatic cancer: Remarkable effort and limited gain

C Yeh, SE Bates - Seminars in Oncology, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is diagnosed
at the locally advanced or metastatic stage in approximately 80% of cases. Relative to other …

[HTML][HTML] Understanding the immune response and the current landscape of immunotherapy in pancreatic cancer

L Ostios-Garcia, J Villamayor… - World journal of …, 2021 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor with high lethality. Even
with surgery, radiotherapy, chemotherapy, and other locoregional or systemic therapies, the …

Current status in chemotherapy for advanced pancreatic adenocarcinoma

H Cao, D Le, LX Yang - Anticancer research, 2013 - ar.iiarjournals.org
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer in the
United States. Surgical resection remains the only curative treatment, but fewer than 20% of …

Pharmacotherapeutic options for pancreatic ductal adenocarcinoma

M Sardar, A Recio-Boiles, K Mody… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy projected to
be the 2nd leading cause of cancer related death in the USA by 2030. This manuscript …