Current techniques to evaluate the efficacy of potential treatments for airways diseases in
preclinical models are generally invasive and terminal. In the past few years, the flexibility of …

Every day, clinicians use imaging to diagnose disease and to assist in therapeutic decision-
making. The value of anatomic imaging of lung structure with X-ray computed tomography …

Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography
(CT), ultrasound (US), positron emission tomography (PET) or single-photon emission …

Mice are commonly used to model human lung diseases. However, their small size poses
substantial problems for accurately measuring lung function. Non-invasive techniques have …

In vivo imaging is increasingly deployed across the drug development process, with
applicability in target identification, compound optimisation and pre-Phase I studies. In vivo …

The pharmaceutical research community has had a longstanding guideline that for
experimental therapeutic preclinical studies at least six animals are required for each data …

In vivo imaging is an important tool for preclinical studies of lung function and disease. The
widespread availability of multimodal animal imaging systems and the rapid rate of …

Small laboratory animals such as mice are being used to understand more about the biology
of human system. This would create a setup where more information is extracted from …

Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …