In patients with stroke and neurodegenerative diseases, overactivation of poly (ADP-ribose)
polymerase-1 (PARP-1) causes harmful effects by inducing apoptosis, necrosis …

Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is
considered to play a crucial role in the development of post-ischemic neuronal injury, such …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after
ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates …

N-[3-(4-Oxo-3, 4-dihydro-phthalazin-1-yl) phenyl]-4-(morpholin-4-yl) butanamide
methanesulfonate monohydrate (ONO-1924H) is a novel inhibitor of poly ADP-ribose …

Poly (ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP …

Background and Purpose—Most stroke patients do not present for medical treatment until
several hours after onset of brain ischemia. Consequently, neuroprotective strategies are …

The brain inflammatory response induced by stroke contributes to cell death and impairs
neurogenesis. Poly (ADP-ribose) polymerase-1 (PARP-1) is a coactivator of the transcription …

Cerebral ischemia induces excessive activation of poly (ADP-ribose) polymerase-1 (PARP-
1), leading to neuronal cell death and the development of post-ischemic dysfunction …

Background and Purpose—Poly (ADP-ribose) polymerase (PARP-1; Enzyme Commission
2.4. 30) is a nuclear DNA repair enzyme that mediates early neuronal ischemic injury. Using …