Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination

ES Geanes, C LeMaster, ER Fraley, S Khanal… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has
resulted in millions of deaths worldwide. Novel coronavirus infections in humans have …

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals

M Jaago, A Rähni, N Pupina, A Pihlak, H Sadam… - Scientific Reports, 2022 - nature.com
Immunity to previously encountered viruses can alter response to unrelated pathogens. We
reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the …

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

H Lv, NC Wu, OTY Tsang, M Yuan, RAPM Perera… - Cell reports, 2020 - cell.com
Summary The World Health Organization has declared the ongoing outbreak of COVID-19,
which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack …

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

Y Li, M Ma, Q Lei, F Wang, W Hong, D Lai, H Hou, Z Xu… - Cell reports, 2021 - cell.com
To fully decipher the immunogenicity of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a …

High-resolution linear epitope mapping of the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 mRNA vaccine recipients

Y Nitahara, Y Nakagama, N Kaku… - Microbiology …, 2021 - Am Soc Microbiol
The prompt rollout of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mRNA vaccine is facilitating population immunity, which is becoming more dominant than …

Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits

S Ravichandran, EM Coyle, L Klenow, J Tang… - Science translational …, 2020 - science.org
Multiple vaccine candidates against SARS-CoV-2 based on viral spike protein are under
development. However, there is limited information on the quality of antibody responses …

Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

M Grobben, K van der Straten, PJM Brouwer… - Elife, 2021 - elifesciences.org
Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …

[HTML][HTML] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses

JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …

[HTML][HTML] Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2

TA Bates, JB Weinstein, HC Leier, WB Messer… - Cell reports, 2021 - cell.com
In the ongoing coronavirus disease 2019 (COVID-19) pandemic, there remain unanswered
questions regarding the nature and significance of the humoral immune response toward …

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

CM Poh, G Carissimo, B Wang, SN Amrun, CYP Lee… - BioRxiv, 2020 - biorxiv.org
The ongoing SARS-CoV-2 pandemic demands rapid identification of immunogenic targets
for the design of efficient vaccines and serological detection tools. In this report, using pools …