Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/β-catenin signaling pathway

Y Yao, L Bian, P Yang, Y Sui, R Li, Y Chen, L Sun, Q Ai… - Brain research, 2019 - Elsevier
Microglia contribute to the regulation of neuroinflammation and play an important role in the
pathogenesis of brain disorders. Thus, regulation of neuroinflammation triggered by …

Upregulated TSG‐6 Expression in ADSCs Inhibits the BV2 Microglia‐Mediated Inflammatory Response

Y Hu, G Li, Y Zhang, N Liu, P Zhang… - BioMed Research …, 2018 - Wiley Online Library
Objectives. The microglial cells are immune surveillance cells in the central nervous system
and can be activated during neurological disorders. Adipose‐derived stem cells (ADSCs) …

Anti-inflammatory action of sulfated glucosamine on cytokine regulation in LPS-activated PMA-differentiated THP-1 macrophages

JA Kim, BN Ahn, CS Kong, SK Kim - Inflammation Research, 2011 - Springer
Objective The aim of this study was to evaluate the effect of sulfated glucosamine (SGlc) on
the regulation of inflammatory cytokines and profiles involved in immunological activities …

Interferon-γ decreases chondroitin sulfate proteoglycan expression and enhances hindlimb function after spinal cord injury in mice

T Fujiyoshi, T Kubo, CCM Chan, M Koda… - Journal of …, 2010 - liebertpub.com
Glial cells, including astrocytes and macrophages/microglia, are thought to modulate
pathological states following spinal cord injury (SCI). In the present study, we evaluated the …

[HTML][HTML] Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in …

W Sheng, Y Zong, A Mohammad, D Ajit, J Cui… - Journal of …, 2011 - Springer
Background Activation of glial cells, including astrocytes and microglia, has been implicated
in the inflammatory responses underlying brain injury and neurodegenerative diseases …

[HTML][HTML] Anti-inflammatory role of GM1 and other gangliosides on microglia

D Galleguillos, Q Wang, N Steinberg, A Zaidi… - Journal of …, 2022 - Springer
Background Gangliosides are glycosphingolipids highly enriched in the brain, with important
roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects …

[HTML][HTML] Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, inflammatory and immunomodulatory conditions

AR Vaz, S Pinto, C Ezequiel, C Cunha… - Frontiers in Cellular …, 2019 - frontiersin.org
Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis
(ALS) involves injury to motor neurons (MNs), activation of glial cells and immune …

Astrocytes in injury states rapidly produce anti‐inflammatory factors and attenuate microglial inflammatory responses

J Kim, KJ Min, W Seol, I Jou, E Joe - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 115, 1161–1171. Abstract Microglia are known to be a primary
inflammatory cell type in the brain. However, microglial inflammatory responses are …

Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes

WL Liu, YH Lee, SY Tsai, CY Hsu, YY Sun, LY Yang… - Glia, 2008 - Wiley Online Library
Reactive gliosis caused by post‐traumatic injury often results in marked expression of
chondroitin sulfate proteoglycan (CSPG), which inhibits neurite outgrowth and regeneration …

Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders

X Yang - Reviews in the Neurosciences, 2020 - degruyter.com
The chondroitin sulfate proteoglycans (CSPGs) are large groups of heterogenous
proteoglycans that are mainly expressed by reactive astrocytes in the central nervous …