Inflammatory cytokines TNFα, IL-1β, and IL-6 are induced in endotoxin-stimulated microglia through different signaling cascades
T Ishijima, K Nakajima - Science Progress, 2021 - journals.sagepub.com
By using an animal model in which inflammatory cytokines are induced in
lipopolysaccharide (LPS)-injected rat brain, we investigated the induction of tumor necrosis …
lipopolysaccharide (LPS)-injected rat brain, we investigated the induction of tumor necrosis …
Effects of a novel GPR55 antagonist on the arachidonic acid cascade in LPS-activated primary microglial cells
SW Saliba, F Gläser, A Deckers, A Keil… - International journal of …, 2021 - mdpi.com
Neuroinflammation is a crucial process to maintain homeostasis in the central nervous
system (CNS). However, chronic neuroinflammation is detrimental, and it is described in the …
system (CNS). However, chronic neuroinflammation is detrimental, and it is described in the …
Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord
Y Liu, G Hammel, M Shi, Z Cheng, S Zivkovic… - Frontiers in Cellular …, 2021 - frontiersin.org
Although the increased expression of members of the chondroitin sulfate proteoglycan
family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to …
family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to …
GLP-2 attenuates LPS-induced inflammation in BV-2 cells by inhibiting ERK1/2, JNK1/2 and NF-κB signaling pathways
N Li, BW Liu, WZ Ren, JX Liu, SN Li, SP Fu… - International Journal of …, 2016 - mdpi.com
The pathogenesis of Parkinson's disease (PD) often involves the over-activation of
microglia. Over-activated microglia could produce several inflammatory mediators, which …
microglia. Over-activated microglia could produce several inflammatory mediators, which …
Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells
S Pugazhenthi, Y Zhang, R Bouchard, G Mahaffey - PloS one, 2013 - journals.plos.org
Proinflammatory cytokines secreted from microglia are known to induce a secondary
immune response in astrocytes leading to an inflammatory loop. Cytokines also interfere …
immune response in astrocytes leading to an inflammatory loop. Cytokines also interfere …
Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve …
T Nishihara, AG Remacle, M Angert, I Shubayev… - Journal of biological …, 2015 - ASBMB
Neuronal glial antigen 2 (NG2) is an integral membrane chondroitin sulfate proteoglycan
expressed by vascular pericytes, macrophages (NG2-Mφ), and progenitor glia of the …
expressed by vascular pericytes, macrophages (NG2-Mφ), and progenitor glia of the …
The attenuating effects of 1, 2, 3, 4, 6 penta-O-galloyl-β-d-glucose on pro-inflammatory responses of LPS/IFNγ-activated BV-2 microglial cells through NFƙB and …
P Mendonca, E Taka, D Bauer, RR Reams… - Journal of …, 2018 - Elsevier
Background Overactivated microglial cells exhibit chronic inflammatory response and can
lead to the continuous production of pro-inflammatory cytokines, perpetuating inflammation …
lead to the continuous production of pro-inflammatory cytokines, perpetuating inflammation …
2, 3, 4′, 5-tetrahydroxystilbene-2-O-β-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating …
SY Park, ML Jin, Z Wang, G Park, YW Choi - Food and Chemical Toxicology, 2016 - Elsevier
Abstract 2, 3, 4′, 5-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG) affects
neuroinflammation-related neurodegenerative diseases and inhibits neuroinflammatory …
neuroinflammation-related neurodegenerative diseases and inhibits neuroinflammatory …
The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
Y Tian, J Milic, LS Monasor, R Chakraborty… - Cellular and Molecular …, 2023 - Springer
Abstract The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a
deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus …
deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus …
Differential regulation of microglial keratan sulfate immunoreactivity by proinflammatory cytokines and colony‐stimulating factors
S Jander, M Schroeter, J Fischer, G Stoll - Glia, 2000 - Wiley Online Library
Resident microglia of the rat CNS express a unique type of keratan sulfate immunoreactivity
(KS‐IR) that is lacking on peripheral monocytes/macrophages and associated with a so far …
(KS‐IR) that is lacking on peripheral monocytes/macrophages and associated with a so far …