NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity

X Lv, R Chen, T Liang, H Peng, Q Fang, S Xiao, S Liu… - Mbio, 2024 - Am Soc Microbiol
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
triggered a global pandemic, which severely endangers public health. Our and others' works …

Circulating ACE2-expressing exosomes block SARS-CoV-2 infection as an innate antiviral mechanism

L El-Shennawy, AD Hoffmann, NK Dashzeveg, PJ Mehl… - BioRxiv, 2020 - biorxiv.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
coronavirus disease 2019 (COVID-19) with innate and adaptive immune response triggered …

Diverse effects of exosomes on COVID-19: a perspective of progress from transmission to therapeutic developments

S Gurunathan, MH Kang, JH Kim - Frontiers in Immunology, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of
coronavirus and the causative agent of the current global pandemic of coronavirus disease …

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

Z Wang, S Hu, KD Popowski, S Liu, D Zhu… - Nature …, 2024 - nature.com
Continued emergence of SARS-CoV-2 variants of concern that are capable of escaping
vaccine-induced immunity highlights the urgency of developing new COVID-19 therapeutics …

Role of endolysosomes in severe acute respiratory syndrome coronavirus-2 infection and coronavirus disease 2019 pathogenesis: implications for potential …

N Khan, X Chen, JD Geiger - Frontiers in pharmacology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-
stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as …

Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

R Yi, R Hashimoto, A Sakamoto, Y Matsumura… - Iscience, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an epidemic
and spread rapidly all over the world. Because the analysis of host factors other than …

The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry

J Zhang, F Huang, B Xia, Y Yuan, F Yu… - … and Targeted Therapy, 2021 - nature.com
Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global
pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus …

[HTML][HTML] NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry

T Han, J Lei, Y Liu, Y Wang, W Xun, Q Hu… - Genes & …, 2023 - ncbi.nlm.nih.gov
Since the end of 2019, COVID-19 has caused worldwide pandemic. SARS-CoV-2, the culprit
of this epidemic, binds to the host receptor Angiotensin converting enzyme 2 (ACE2) using …

SARS-CoV-2 takes the bait: Exosomes as endogenous decoys

S Fernbach, BG Hale - PLoS Biology, 2022 - journals.plos.org
Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are
deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with …

Exosomes, and the potential for exosome‐based interventions against COVID‐19

A Rahmani, A Soleymani, M Almukhtar… - Reviews in Medical …, 2024 - Wiley Online Library
Since late 2019, the world has been devastated by the coronavirus disease 2019 (COVID‐
19) induced by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), with more …