Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic
variants have been defined only in a fairly small subset of cases. The enormous genetic …

Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …

Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …

Autism is a clinically and genetically heterogeneous neurodevelopmental disorder. Although
multiple genes, risk alleles and copy number variants (CNVs) have been implicated in ASD …

The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major
challenge. Recent advances in genetic screening and systems biology approaches have …

Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Research during the past decade has seen significant progress in the understanding of the
genetic architecture of autism spectrum disorders (ASDs), with gene discovery accelerating …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. Recently developed genomic technologies, including microarray and next …

Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …

Highlights•Exome sequencing on unprecedented scale has identified 400 genes associated
with ASD and NDD.•Functional networks disrupted in NDD converge on distinct …