RECENT studies that intracerebroventricular (icv) administration of orphanin FQ (OFQ)
blocks opioidinduced antinociception in a variety of animal models of pain. In the present …

We assessed whether tolerance develops to the antinociceptive effect of intrathecal (it)
orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is …

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like
receptor, LC132. Initial reports suggested that OFQ increased pain sensitivity when injected …

Orphanin FQ (OFQ, also known as nociceptin) has been proposed to oppose the
antinociceptive effect of endogenous opioid peptides in the brain. We sought to determine …

Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was
recently isolated and characterized. The anti-opioid role of OFQ in supraspinal pain …

Abstract ORPHANIN FQ or nociceptin (OFQ/N 1-17) is a recently discovered peptide which,
upon intracerebroventricular administration, reverses opioid-mediated analgesias. OFQ/N 1 …

Recent evidence from studies in mice lacking the opioid receptor‐like (ORL‐1) receptor and
from experiments using antibodies raised against orphanin FQ/nociceptin (OFQ/N) suggest …

RECENT studies suggest that the novel opioid peptide orphanin FQ (OFQ) is involved in
pain modulation. We found that intracerebroventricular (icv) administration of OFQ in the rat …

Orphanin FQ/nociceptin (OFQ) is a recently discovered endogenous ligand for the novel
opioid receptor-like receptor (ORL-1). There are numerous reports in the literature …

It is well known that dorsal raphe nucleus (DRN) is one of the key structures for the
development of opioid analgesia and tolerance. An increased activity of 'antiopioids' like …