HIV drug resistance among children initiating first-line antiretroviral treatment in Uganda

C Kityo, KCE Sigaloff, TS Boender… - AIDS research and …, 2016 - liebertpub.com
Background: There are limited data on primary human immunodeficiency virus drug
resistance (HIVDR) in pediatric populations. This study aimed to assess the prevalence of …

Antiretroviral drug resistance profiles and response to second-line therapy among HIV type 1-infected Ugandan children

V Musiime, E Kaudha, J Kayiwa, G Mirembe… - AIDS research and …, 2013 - liebertpub.com
We sought to determine the pattern of resistance-associated mutations (RAMs) among HIV-1-
infected children failing first-line antiretroviral therapy (ART) and ascertain their response to …

[HTML][HTML] Development of HIV drug resistance and therapeutic failure in children and adolescents in rural Tanzania: an emerging public health concern

L Muri, A Gamell, AJ Ntamatungiro, TR Glass… - Aids, 2017 - journals.lww.com
Objective: To investigate the prevalence and determinants of virologic failure and acquired
drug resistance-associated mutations (DRMs) in HIV-infected children and adolescents in …

Drug resistance among newly diagnosed HIV-infected children in the era of more efficacious antiretroviral prophylaxis

L Kuhn, G Hunt, KG Technau, A Coovadia, J Ledwaba… - Aids, 2014 - journals.lww.com
Background: In the era of more efficacious prevention of mother-to-child transmission
(PMTCT) regimens, documenting the profile of drug resistance in HIV-infected infants and …

high rates of thymidine analogue mutations and dual-class resistance among HIV-infected Ugandan children failing first-line antiretroviral therapy

KCE Sigaloff, J Kayiwa, V Musiime… - AIDS research and …, 2013 - liebertpub.com
HIV-infected children are at high risk of acquiring drug-resistant viruses, which is of
particular concern in settings where antiretroviral drug options are limited. We aimed to …

Surveillance of antiretroviral drug resistance mutations in untreated young children living in the Central African Republic

C Charpentier, JC Gody, P Tisserand, M Matta, H Péré… - 2011 - journals.sagepub.com
Background A survey of drug resistance-associated mutations (DRMs) was conducted in
2009 among 77 vertically HIV-infected children not treated by antiretroviral drugs, followed …

[HTML][HTML] Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort

S Pillay, RM Bland, RJ Lessells, J Manasa… - AIDS research and …, 2014 - Springer
Background Better understanding of drug resistance patterns in HIV-infected children on
antiretroviral therapy (ART) is required to inform public health policies in high prevalence …

Alarming increase in pretreatment HIV drug resistance in children living in sub-Saharan Africa: a systematic review and meta-analysis

RS Boerma, KCE Sigaloff, AS Akanmu… - Journal of …, 2017 - academic.oup.com
Background: Children have an augmented risk of pretreatment HIV drug resistance (PDR)
due to exposure to antiretroviral drugs for the prevention of mother-to-child transmission …

Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital

C Bratholm, A Johannessen, E Naman… - Journal of …, 2010 - academic.oup.com
Objectives To assess long-term virological efficacy and the emergence of drug resistance in
children who receive antiretroviral treatment (ART) in rural Tanzania. Patients and methods …

Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India

M Kumar, S Sen, RK Gupta, D Chaturbhuj… - AIDS research and …, 2014 - liebertpub.com
We report the presence of drug resistance mutations in 7.4%(2/27) of the treatment-naive,
HIV-1-infected children in Pune, India, who had HIV-1 RNA levels> 1,000 copies/ml …