Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
Potential Therapeutic Strategies for Alzheimer's Disease Targeting or Beyond β‐Amyloid: Insights from Clinical Trials
Q Jia, Y Deng, H Qing - BioMed research international, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β‐
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …
The Aβ hypothesis: leading us to rationally‐designed therapeutic strategies for the treatment or prevention of Alzheimer disease
TE Golde - Brain pathology, 2005 - Wiley Online Library
In recent years the amyloid cascade hypothesis of Alzheimer disease (AD) has been
increasingly referred to as the amyloid β protein (Aβ) cascade hypothesis. This subtle …
increasingly referred to as the amyloid β protein (Aβ) cascade hypothesis. This subtle …
Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
TE Golde, LS Schneider, EH Koo - Neuron, 2011 - cell.com
Most current Alzheimer's disease (AD) therapies in advanced phases of development target
amyloid β-peptide (Aβ) production, aggregation, or accumulation. Translational models …
amyloid β-peptide (Aβ) production, aggregation, or accumulation. Translational models …
[PDF][PDF] β Amyloid hypothesis in Alzheimer's disease: pathogenesis, prevention, and management
H Zhang, Y Zheng - Acta Academiae Medicinae …, 2019 - journal13.magtechjournal.com
Alzheimer's disease (AD) is a central nervous system disease characterized by progressive
cognitive dysfunction and memory loss. Increasing evidences suggest that β amyloid (Aβ) …
cognitive dysfunction and memory loss. Increasing evidences suggest that β amyloid (Aβ) …
Aspects of β-amyloid as a biomarker for Alzheimer's disease
U Andreasson, E Portelius, ME Andersson… - Biomarkers in …, 2007 - Taylor & Francis
Alzheimer's disease is an age-related neurodegenerative disorder that results in
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …
[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …
affecting around 46 million people worldwide but few treatments are currently available. The …
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Revisiting the amyloid cascade hypothesis: from anti-Aβ therapeutics to auspicious new ways for Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder related to age,
characterized by the cerebral deposition of fibrils, which are made from the amyloid-β (Aβ), a …
characterized by the cerebral deposition of fibrils, which are made from the amyloid-β (Aβ), a …
[HTML][HTML] Amyloid cascade hypothesis for the treatment of alzheimer's disease: progress and challenges
T Wu, D Lin, Y Cheng, S Jiang, MW Riaz, N Fu… - Aging and …, 2022 - ncbi.nlm.nih.gov
The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …