Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Potential Therapeutic Strategies for Alzheimer's Disease Targeting or Beyond β‐Amyloid: Insights from Clinical Trials

Q Jia, Y Deng, H Qing - BioMed research international, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β‐
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …

The Aβ hypothesis: leading us to rationally‐designed therapeutic strategies for the treatment or prevention of Alzheimer disease

TE Golde - Brain pathology, 2005 - Wiley Online Library
In recent years the amyloid cascade hypothesis of Alzheimer disease (AD) has been
increasingly referred to as the amyloid β protein (Aβ) cascade hypothesis. This subtle …

Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

TE Golde, LS Schneider, EH Koo - Neuron, 2011 - cell.com
Most current Alzheimer's disease (AD) therapies in advanced phases of development target
amyloid β-peptide (Aβ) production, aggregation, or accumulation. Translational models …

[PDF][PDF] β Amyloid hypothesis in Alzheimer's disease: pathogenesis, prevention, and management

H Zhang, Y Zheng - Acta Academiae Medicinae …, 2019 - journal13.magtechjournal.com
Alzheimer's disease (AD) is a central nervous system disease characterized by progressive
cognitive dysfunction and memory loss. Increasing evidences suggest that β amyloid (Aβ) …

Aspects of β-amyloid as a biomarker for Alzheimer's disease

U Andreasson, E Portelius, ME Andersson… - Biomarkers in …, 2007 - Taylor & Francis
Alzheimer's disease is an age-related neurodegenerative disorder that results in
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …

[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

F Panza, M Lozupone, G Logroscino… - Nature Reviews …, 2019 - nature.com
Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …

Revisiting the amyloid cascade hypothesis: from anti-Aβ therapeutics to auspicious new ways for Alzheimer's disease

MS Uddin, MT Kabir, MS Rahman, T Behl… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder related to age,
characterized by the cerebral deposition of fibrils, which are made from the amyloid-β (Aβ), a …

[HTML][HTML] Amyloid cascade hypothesis for the treatment of alzheimer's disease: progress and challenges

T Wu, D Lin, Y Cheng, S Jiang, MW Riaz, N Fu… - Aging and …, 2022 - ncbi.nlm.nih.gov
The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …