Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder

S Maahs, D Leclair, B Gomez-Mancilla, BD Kiluk… - Frontiers in …, 2024 - frontiersin.org
Background Cocaine use disorder (CUD) is characterized by the continued use of cocaine
despite serious impacts on life. This study focused on understanding the perspective of …

Cocaine use disorder (CUD): current clinical perspectives

EKC Schwartz, NR Wolkowicz… - Substance Abuse and …, 2022 - Taylor & Francis
Cocaine use disorder (CUD) is a devastating disorder, impacting both individuals and
society. Individuals with CUD face many barriers in accessing treatment for CUD, and most …

Short and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders

AQC Miguel, BD Kiluk, TA Babuscio, C Nich… - Drug and Alcohol …, 2019 - Elsevier
Background Substantial efforts have been made to identify clinically meaningful non-
abstinence cocaine use outcomes by establishing associations between targeted drug use …

Pharmacotherapeutic strategies for treating cocaine use disorder—what do we have to offer?

L Brandt, T Chao, SD Comer, FR Levin - Addiction, 2021 - Wiley Online Library
Background Cocaine use contines to be a significant public health problem world‐wide.
However, despite substantial research efforts, no pharmacotherapies are approved for the …

Understanding the patient and supporter journey in cocaine use disorder

D Leclair, KM Waye, B Gomez-Mancilla… - Frontiers in …, 2024 - frontiersin.org
Background There is a paucity of literature describing experiences and journey of
individuals with cocaine use disorder (CUD) and supporters who care for them. The aim of …

Predictors of cocaine use disorder treatment outcomes: a systematic review

A Palazón-Llecha, B Caparrós, J Trujols… - Systematic …, 2024 - Springer
Background Psychosocial approaches are the first-line treatments for cocaine dependence,
although they still present high dropout and relapse rates. Thus, there is a pressing need to …

Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder

CR Roos, C Nich, CJ Mun, TA Babuscio… - Drug and alcohol …, 2019 - Elsevier
Background Despite calls for non-abstinence endpoints in randomized clinical trials (RCTs)
for cocaine use disorder, there is a lack of data validating non-abstinence endpoints. We …

Pharmacotherapy for cocaine use disorder—a systematic review and meta-analysis

B Chan, K Kondo, M Freeman, C Ayers… - Journal of general …, 2019 - Springer
Background Currently, there are no accepted FDA-approved pharmacotherapies for cocaine
use disorder, though numerous medications have been tested in clinical trials. We …

Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race

AQC Miguel, A Jordan, BD Kiluk, C Nich… - Journal of substance …, 2019 - Elsevier
Background Most published treatment trials for cocaine use disorders (CUD) have been
conducted with samples composed predominantly of White men and underrepresent women …

Pharmacological treatments for cocaine craving: what is the way forward? A systematic review

DLS Lassi, A Malbergier, AB Negrao, L Florio… - Brain Sciences, 2022 - mdpi.com
Background: cocaine craving is a core feature of cocaine use disorder and remains a critical
challenge for abstinence and relapse prevention. This review summarizes the anti-craving …