Background Sleep problems tend to vary according to the course of the disorder in
individuals with mental health problems. Research in mental health has associated sleep …

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics
has highlighted the importance of drug dosing-time. Circadian oscillations alter drug …

BACKGROUND: Diurnal variation in mood is a prominent symptom of depression, and is
typically experienced as positive mood variation (PMV—mood being worse upon waking …

Depression is a multifaceted illness with large interindividual variability in clinical response
to treatment. In the era of digital medicine and precision therapeutics, new personalized …

The use of digital tools to measure physiological and behavioural variables of potential
relevance to mental health is a growing field sitting at the intersection between computer …

While studies show links between smartphone data and affective symptoms, we lack clarity
on the temporal scale, specificity (eg, to depression vs. anxiety), and person-specific (vs …

The cyclic nature of depressive illness, disturbance of diurnal mood variations, and
disturbed sleep–wake and physiological rhythms all suggest that dysfunction of the …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Background: While preliminary evidence suggests that sensors may be employed to detect
presence of low mood it is still unclear whether they can be leveraged for measuring …

Background There is a need to identify biomarkers of treatment outcomes for major
depressive disorder (MDD) that can be disseminated. We investigated the predictive utility of …