Macrophages and immune cells in atherosclerosis: recent advances and novel concepts

C Cochain, A Zernecke - Basic research in cardiology, 2015 - Springer
Atherosclerotic lesion-related thrombosis is the major cause of myocardial infarction and
stroke, which together constitute the leading cause of mortality worldwide. The inflammatory …

Monocytes in atherosclerosis: subsets and functions

KJ Woollard, F Geissmann - Nature Reviews Cardiology, 2010 - nature.com
Chronic inflammation drives atherosclerosis, the leading cause of cardiovascular disease.
Over the past two decades, data have emerged showing that immune cells are involved in …

Vascular macrophages in atherosclerosis

H Xu, J Jiang, W Chen, W Li… - Journal of immunology …, 2019 - Wiley Online Library
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular
diseases, the leading global health threat, and a great burden for society. It has been well …

[HTML][HTML] Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

J Nagenborg, P Goossens, EAL Biessen… - European journal of …, 2017 - Elsevier
Macrophages are key players in atherosclerotic lesions, regulating the local inflammatory
milieu and plaque stability by the secretion of many inflammatory molecules, growth factors …

The role of monocytes and macrophages in human atherosclerosis, plaque neoangiogenesis, and atherothrombosis

F Moroni, E Ammirati, GD Norata… - Mediators of …, 2019 - Wiley Online Library
Atherosclerosis is one of the leading causes of death and disability worldwide. It is a
complex disease characterized by lipid accumulation within the arterial wall, inflammation …

Macrophages and their contribution to the development of atherosclerosis

YV Bobryshev, NG Nikiforov, NV Elizova… - … : Origin, Functions and …, 2017 - Springer
Atherosclerosis can be regarded as chronic inflammatory disease driven by lipid
accumulation in the arterial wall. Macrophages play a key role in the development of local …

Immune and inflammatory mechanisms of atherosclerosis

E Galkina, K Ley - Annual review of immunology, 2009 - annualreviews.org
Atherosclerosis is an inflammatory disease of the wall of large-and medium-sized arteries
that is precipitated by elevated levels of low-density lipoprotein (LDL) cholesterol in the …

Atherosclerosis and immunity: a perspective

F Abdolmaleki, SMG Hayat, V Bianconi… - Trends in cardiovascular …, 2019 - Elsevier
Atherosclerosis is an inflammatory and multifaceted disorder resulting from the accumulation
of lipid droplets and several types of immune cells, including macrophages, T and B …

Macrophage subsets in atherosclerosis

G Chinetti-Gbaguidi, S Colin, B Staels - Nature Reviews Cardiology, 2015 - nature.com
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. In
atherosclerotic lesions, macrophages respond to various environmental stimuli, such as …

The dynamic lives of macrophage and dendritic cell subsets in atherosclerosis

PL Taghavie‐Moghadam, MJ Butcher… - Annals of the New …, 2014 - Wiley Online Library
Atherosclerosis, the major pathological process through which arterial plaques are formed,
is a dynamic chronic inflammatory disease of large‐and medium‐sized arteries in which the …