Background & Aims The development of hepatic models capable of long-term expansion
with competent liver functionality is technically challenging in a personalized setting. Stem …

A growing number of in vitro hepatic models exist to study human genetics, liver biology,
disease modeling and drug development and range from 2D hepatocytes to 3D multi …

Background & Aims Human induced pluripotent stem cell (hiPSC)-derived liver modeling
systems have the potential to overcome the shortage of donors for clinical application and …

Human in vitro hepatic models that faithfully recapitulate liver function are essential for
successful basic and translational research. A limitation of current in vitro models, which are …

Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed to …

Organoid technology provides a revolutionary paradigm toward therapy but has yet to be
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …

Liver organoids represent emerging human-relevant in vitro liver models that have a wide
range of biomedical applications in basic medical studies and preclinical drug discovery …

“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

Despite advances in stem cell research, cell transplantation therapy for liver failure is
impeded by a shortage of human primary hepatocytes (HPH), along with current …