Simple Summary In this preclinical in-vivo study, we used an orthotopic prostate cancer
mouse model to analyze the effects of primary tumor resection on further disease …

Metastatic prostate cancer (mPCa) is one of the most prevalent cancers in men worldwide.
The main cause of death in these patients is androgen-resistant metastatic disease. Surgery …

To study the multifaceted biology of prostate cancer, pre-clinical in vivo models offer a range
of options to uncover critical biological information about this disease. The human orthotopic …

Our laboratory has developed a novel orthotopic implantation model of human prostate
cancer (PCa). As PCa death is not due to the primary tumor, but rather the formation of …

The complex dynamics of the tumor microenvironment and prostate cancer heterogeneity
have confounded efforts to establish suitable preclinical mouse models to represent human …

BACKGROUND Prostate cancer is the second leading cause of male death in the United
States. When diagnosed, nearly half the cases have metastatic lesions. An animal model of …

The 5-year survival rate for patients diagnosed with distant metastatic prostate cancer in the
United States is 30.6%. Therefore, there is a great need to develop in vivo model systems to …

BACKGROUND An animal model of human prostate cancer LNCaP demonstrating high
rates of spontaneous metastasis from the orthotopic site after tumor implantation would be …

We developed a sensitive real-time polymerase chain reaction (QPCR) assay that allows us
to track early lodging/homing events in vivo. We used this technology to develop a …

Metastasis is the major cause of prostate cancer deaths and there is a need for clinically
relevant in vivo models allowing elucidation of molecular and cellular mechanisms …