Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

Proteinuria serves as a direct causative factor of renal tubular cell injury and is highly
associated with the progression of chronic kidney disease via uncertain mechanisms …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney
fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator …

Endoplasmic reticulum (ER) stress and mitochondrial dysfunction, which are key events in
the initiation and/or progression of several diseases, are correlated with alterations at ER …

NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐or danger‐
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …

The NLRP3 inflammasome, as an important component of the innate immune system, plays
vital roles in various metabolic disorders. It has been reported that the NLRP3 …

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern
recognition receptor that is implicated in the pathogenesis of inflammation and chronic …

Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to
infection, while the accompanying acute kidney injury (AKI) is linked to significant incidence …