Kidney in diabetic state is more sensitive to ischemic acute kidney injury (AKI). However, the
underlying mechanisms remain unclear. Herein, we examined the impact of diabetes …

Rationale LonP1 is an essential mitochondrial protease, which is crucial for maintaining
mitochondrial proteostasis and mitigating cell stress. However, the importance of LonP1 …

Lung injury, which is associated with systemic inflammatory responses, is a common
problem with significant morbidity and mortality. Here, we examined the involvement of toll …

Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form
inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D …

Acute lung injury (ALI), known a severe disease along with high morbidity and mortality, is
lacking of specific therapies. Inflammation, apoptosis and oxidative stress are critical …

Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

The NLRP3-inflammasome complex has emerged as an important component of
inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study …

Reactive oxygen species (ROS) produced by tumor necrosis factor-α (TNF-α) have an
important function in cell death by activating c-Jun N-terminal kinase. However, the exact …

Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …

Background: We previously reported that the NLRP3 inflammasome played an important
role in mediating the podocyte injury induced by aldosterone. However, more studies on the …