Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are responsible for autosomal
dominant and sporadic Parkinson disease (PD), possibly exerting their effects via a toxic …

Deteriorating kidney function is frequently observed in the elderly population, as well as
vulnerability to acute kidney failure, such as ischemic/reperfusion injury (IRI), and …

Abstract Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly
expressed in tissues of endodermal origin, where its physiological role has been extensively …

ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have
been implicated in TNFα (tumour necrosis factor α)-mediated signalling. In the present study …

Inflammation plays a key role in the pathophysiology of hepatic ischemia–reperfusion (I/R)
injury. However, the mechanism by which hepatic I/R induces inflammatory responses …

Ischemia/reperfusion injury triggers acute kidney injury (AKI) by aggravating oxidative stress
mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma …

Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome Page 1 Dangerous
Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome Fabio Martinon1,* 1Department …

Ischemia/reperfusion injury is a major cause of acute kidney injury. Improving renal repair
would represent a therapeutic strategy to prevent renal dysfunction. The innate immune …

NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …