Inflammation plays a key role in the pathophysiology of hepatic ischemia–reperfusion (I/R)
injury. However, the mechanism by which hepatic I/R induces inflammatory responses …

Ischemia/reperfusion injury triggers acute kidney injury (AKI) by aggravating oxidative stress
mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …

Mutations in the NGLY1 (N-glycanase 1) gene, encoding an evolutionarily conserved
deglycosylation enzyme, are associated with a rare congenital disorder leading to global …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Background. Acute kidney injury (AKI) is one of the common complications of sepsis.
Heretofore, there is no effective treatment for septic AKI. Recent studies have revealed that …

Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with
several human diseases. It has been widely reported that ER stress kills through activation …

Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to
mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry …

Dying cells are capable of activating the innate immune system and inducing a sterile
inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 …