The role of GSK‐3 in synaptic plasticity

S Peineau, C Bradley, C Taghibiglou… - British journal of …, 2008 - Wiley Online Library
Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism
pathway, is highly expressed in the CNS. It has been implicated in major neurological …

A pivotal role of GSK-3 in synaptic plasticity

CA Bradley, S Peineau, C Taghibiglou… - Frontiers in molecular …, 2012 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …

LTP inhibits LTD in the hippocampus via regulation of GSK3β

S Peineau, C Taghibiglou, C Bradley, TP Wong, L Liu… - Neuron, 2007 - cell.com
Summary Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological
disorders, but its role in normal neuronal function is largely unknown. Here we show that …

Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons

P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPET
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key
regulatory kinase involved in a plethora of processes in the nervous system, including …

Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation

C Hooper, V Markevich, F Plattner… - European journal of …, 2007 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating
diverse cellular functions including metabolism, transcription and cell survival. Numerous …

GSK‐3β at the Intersection of Neuronal Plasticity and Neurodegeneration

T Jaworski, E Banach-Kasper, K Gralec - Neural plasticity, 2019 - Wiley Online Library
In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3

T Engel, F Hernández, J Avila… - Journal of Neuroscience, 2006 - Soc Neuroscience
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a …

Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

LQ Zhu, SH Wang, D Liu, YY Yin, Q Tian… - Journal of …, 2007 - Soc Neuroscience
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …

AZD 1080, a novel GSK 3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

B Georgievska, J Sandin, J Doherty… - Journal of …, 2013 - Wiley Online Library
Abnormal tau phosphorylation resulting in detachment of tau from microtubules and
aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary …

GSK3β isoform‐selective regulation of depression, memory and hippocampal cell proliferation

M Pardo, E Abrial, RS Jope… - Genes, brain and …, 2016 - Wiley Online Library
Abnormally active glycogen synthase kinase‐3 (GSK3) contributes to pathological
processes in multiple psychiatric and neurological disorders. Modeled in mice, this includes …