The role of GSK‐3 in synaptic plasticity
S Peineau, C Bradley, C Taghibiglou… - British journal of …, 2008 - Wiley Online Library
Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism
pathway, is highly expressed in the CNS. It has been implicated in major neurological …
pathway, is highly expressed in the CNS. It has been implicated in major neurological …
A pivotal role of GSK-3 in synaptic plasticity
CA Bradley, S Peineau, C Taghibiglou… - Frontiers in molecular …, 2012 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …
LTP inhibits LTD in the hippocampus via regulation of GSK3β
Summary Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological
disorders, but its role in normal neuronal function is largely unknown. Here we show that …
disorders, but its role in normal neuronal function is largely unknown. Here we show that …
Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons
P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPET
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key
regulatory kinase involved in a plethora of processes in the nervous system, including …
regulatory kinase involved in a plethora of processes in the nervous system, including …
Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation
C Hooper, V Markevich, F Plattner… - European journal of …, 2007 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating
diverse cellular functions including metabolism, transcription and cell survival. Numerous …
diverse cellular functions including metabolism, transcription and cell survival. Numerous …
GSK‐3β at the Intersection of Neuronal Plasticity and Neurodegeneration
T Jaworski, E Banach-Kasper, K Gralec - Neural plasticity, 2019 - Wiley Online Library
In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …
critical processes underlying structural and functional synaptic plasticity. Mouse models with …
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
T Engel, F Hernández, J Avila… - Journal of Neuroscience, 2006 - Soc Neuroscience
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a …
that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a …
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
LQ Zhu, SH Wang, D Liu, YY Yin, Q Tian… - Journal of …, 2007 - Soc Neuroscience
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …
AZD 1080, a novel GSK 3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans
B Georgievska, J Sandin, J Doherty… - Journal of …, 2013 - Wiley Online Library
Abnormal tau phosphorylation resulting in detachment of tau from microtubules and
aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary …
aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary …
GSK3β isoform‐selective regulation of depression, memory and hippocampal cell proliferation
Abnormally active glycogen synthase kinase‐3 (GSK3) contributes to pathological
processes in multiple psychiatric and neurological disorders. Modeled in mice, this includes …
processes in multiple psychiatric and neurological disorders. Modeled in mice, this includes …