The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Summary TSLP, IL-25, and IL-33 are increasingly recognized to play important roles in the
pathophysiology of allergic diseases. More clear recognition of the differences and …

The interaction between the airway epithelium and the inhaled environment is crucial to
understanding the pathobiology of asthma. Several studies have identified an important role …

Cytokines are critical in allergic intercellular communication networks, and they contribute to
disease pathology through the recruitment and activation of pro-inflammatory leukocytes …

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and
air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal …

Highlights•The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic
inflammation at mucosal surfaces.•The precise function of these cytokines during human …

Type-2 innate immune responses that occur in airways and are accompanied by goblet-cell
hyperplasia and mucus production are largely driven by interleukin-33 (IL-33) and natural …

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine important for the
initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this …

Background IL-33 plays an important role in the development of experimental asthma.
Objective We sought to study the role of the IL-33 receptor suppressor of tumorigenicity 2 …

Background The epithelial cell‐derived danger signal mediators thymic stromal
lymphopoietin (TSLP) and IL‐33 are consistently associated with adaptive Th2 immune …