Peroxisomes require the translocation of folded and functional target proteins of various
sizes across the peroxisomal membrane. We have investigated the structure and function of …

This chapter concerns one branch of the peroxisome import pathway for newly-synthesized
peroxisomal proteins, specifically the branch for matrix proteins that contain a peroxisome …

The majority of peroxisomal matrix proteins are recognized by the import receptor Pex5p.
The receptor is dynamic in terms of its overall architecture and association with the …

Peroxisomes transport folded and oligomeric proteins across their membrane. Two cytosolic
import receptors, Pex5p and Pex7p, along with approximately 12 membrane-bound …

Peroxisomal proteins carrying a peroxisome targeting signal type 1 (PTS1) are recognized
in the cytosol by the cycling import receptor Pex5p. The receptor-cargo complex docks at the …

Peroxisomes are a family of organelles which have many unusual features. They can arise
de novo from the endoplasmic reticulum by a still poorly characterized process, yet possess …

PEX5 functions as a mobile import receptor for peroxisomal matrix proteins with a
peroxisomal targeting signal 1 (PTS1). A critical step within the PTS1-import pathway is the …

Background: How the soluble receptor PEX5 delivers its cargoes to the peroxisome remains
largely unknown. Results: Cargo translocation occurs after docking of the receptor at the …

The import of proteins into the peroxisome matrix is an essential step in peroxisome
biogenesis, which is critical for normal functioning of most eukaryotic cells. The translocation …

Targeting of peroxisomal matrix and membrane proteins is performed by distinct transport
machineries and requires the concerted action of at least 23 peroxins. Cargo recognition …