Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster …
J Van Benthem, VJ Feron, WR Leeman… - …, 1994 - academic.oup.com
The present paper reports about an immunocytochemical inventory of the cell types involved
in the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3 …
in the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3 …
Accumulation and Persistence of DNA Adducts in Respiratory Tissue of Rats following Multiple Administrations of the Tobacco Specific Carcinogen 4-(N-Methyl-N …
SA Belinsky, CM White, JA Boucheron, FC Richardson… - Cancer Research, 1986 - AACR
(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a major nitrosamine formed in
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
Dose-Response Relationship between O6-Methylguanine Formation in Clara Cells and Induction of Pulmonary Neoplasia in the Rat by 4-(Methylnitrosamino)-1-(3 …
SA Belinsky, JF Foley, CM White, MW Anderson… - Cancer research, 1990 - AACR
The relationship between the formation of O 6-methylguanine (O6MG) and the induction of
lung, liver, and nasal tumors in the Fischer 344 rat by the tobacco-specific nitrosamine 4 …
lung, liver, and nasal tumors in the Fischer 344 rat by the tobacco-specific nitrosamine 4 …
Immunocytochemical localization of DNA adducts induced by a single dose of N-nitroso-N-methylbenzylamine in target and non-target tissues of tumor formation in …
J Van Benthem, CP Wild, E Vermeulen… - …, 1991 - europepmc.org
The formation and short-term persistence of O6-methylguanine (O6-meGua) and 7-
methylguanine (7-meGua) in individual cells of various target and non-target tissues for …
methylguanine (7-meGua) in individual cells of various target and non-target tissues for …
Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N …
JV Benthem, E Vermeulen, HHK Winterwerp… - …, 1992 - academic.oup.com
The distribution and accumulation of O 6-methylguanine (O 6-meGua) and 7-methylguanine
(7-meGua) was investigated immunocytochemically in target and non-target tissues of rats …
(7-meGua) was investigated immunocytochemically in target and non-target tissues of rats …
Measurement of O 6 -methyldeoxyguanosine in DNA methylated by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone …
PG Foiles, N Trushin, A Castonguay - Carcinogenesis, 1985 - academic.oup.com
Rabbit antibodies raised against O 6-methy1-2'-deoxyguanosine (O 6-MedGuo) were used
to develop a competitive BiotinAvidin enzyme-linked immunosorbent assay (BA-ELISA) for …
to develop a competitive BiotinAvidin enzyme-linked immunosorbent assay (BA-ELISA) for …
Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methyhiitrosamine)-l-(3-pyridyl)-1 …
FL Chung, Y Xu - Carcinogenesis, 1992 - academic.oup.com
Evidence for the involvement of free radicals in nitrosamine carcinogenesis comes mainly
from increased lipid peroxidation as a result of nitrosamine treatment. More direct evidence …
from increased lipid peroxidation as a result of nitrosamine treatment. More direct evidence …
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N …
SS Hecht, TE Spratt, N Trushin - Carcinogenesis, 1988 - academic.oup.com
DNA was isolated from tissues of K344 rats 24 h after treatment by sc injection with [5-3 H] 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5-3 H] NNK) or [5-3 H] N′-nitrosonor …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone ([5-3 H] NNK) or [5-3 H] N′-nitrosonor …
Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
A Castonguay, R Tharp, SS Hecht - IARC scientific publications, 1984 - europepmc.org
The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was injected
intravenously (0.41 mmol/kg) into F344 rats. DNA from target organs (lung, liver) and a non …
intravenously (0.41 mmol/kg) into F344 rats. DNA from target organs (lung, liver) and a non …
Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
L Liu, A Castonguay, SL Gerson - Carcinogenesis, 1992 - academic.oup.com
Previous studies have demonstrated that the tobacco-specific nitrosamine 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced liver tumors in F344 rats but …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced liver tumors in F344 rats but …
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- dna methylation f344 rats
- respiratory tissue dna adducts
- immunocytochemical localization dna adducts
- tumor formation dna adducts
- respiratory tissue accumulation and persistence
- lack of correlation rats and hamsters
- accumulation and persistence dna adducts
- dna methylation rats and hamsters
- lung dna f344 rats
- dna methylation hepatocarcinogenesis in rats