Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation
for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal …

Spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and, thus,
preservation of a species. Because of stem cell rarity, studying their self-renewal is greatly …

Spermatogenesis requires that a careful balance be maintained between the self-renewal of
spermatogonial stem cells (SSCs) and their commitment to the developmental pathway …

Chromodomain helicase/ATPase DNA binding protein 1‐like gene (Chd1l) participates in
chromatin‐dependent processes, including transcriptional activation and DNA repair. In this …

Spermatogenesis is sustained by homeostatic balance between the self-renewal and
differentiation of spermatogonial stem cells, which is dependent on the strict regulation of …

Germ cells are thought to exhibit a unique DNA damage response that differs from that of
somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival …

A small number of offspring are born from the numerous sperm generated from
spermatogonial stem cells (SSCs). However, little is known regarding the rules and …

The ability of men to remain fertile throughout their lives depends upon establishment of a
spermatogonial stem cell (SSC) pool from gonocyte progenitors, and thereafter balancing …

Abstract 53BP1 mediates DNA repair process in somatic cells; however, the function of
53BP1 in germline stem cells still remains unclear. In the present study, animals and cells …

Fibroblast growth factor 2 (FGF2) and glial cell line-derived neurotrophic factor (GDNF) are
required to recapitulate spermatogonial stem cell (SSC) self-renewal in vitro. Although …