Microtubule-poisoning drugs, such as Paclitaxel (or Taxol, PTX), are powerful and
commonly used anti-neoplastic agents for the treatment of several malignancies. PTX …

Paclitaxel (PTX) and other microtubule inhibitors cause mitotic arrest. However, low
concentrations of PTX (low PTX) paradoxically cause G1 arrest (without mitotic arrest). Here …

Abstract Irinotecan (CPT‐11), a recently introduced component of a standard chemotherapy
for colorectal cancer, induces in colon cancer cell lines in vitro cell cycle arrest and …

7-Hydroxystaurosporine (UCN-01) is a potent inhibitor of protein kinase C (PKC) isozymes
alpha, beta, and gamma [Seynaeve et al., Mol. Pharmacol, 45: 1207-1214, 1994] that also …

Background At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs
mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to …

Abstract Treatment of solid tumors with combinations of chemotherapeutic agents has not
led to significant increases in long-term survival. Recent studies support a role for inhibitors …

UCN-01 (7-hydroxyl-staurosporine), which was initially developed as a selective protein
kinase C inhibitor, has an anti-tumor effect on several human cancer cell linesin vivo. In this …

A checkpoint operating in the G 2 phase of the cell cycle prevents entry into mitosis in the
presence of DNA damage. UCN-01, a protein kinase inhibitor currently undergoing clinical …

We have previously reported the inhibitory effect of NCX-4016, a nitro derivative of aspirin,
on the proliferation of cisplatin-resistant human ovarian cancer cells, in vitro (Bratasz et al …

Components of the cell cycle machinery are frequently altered in cancer. Many of these
alterations affect the cyclin-dependent kinases (CDKs) and their regulation. Staurosporine …