Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis
The 70 kDa ribosomal S6 kinase (p70S6K) is important for cell growth and survival.
Activation of p70S6K requires sequential phosphorylation of multiple serine and threonine …
Activation of p70S6K requires sequential phosphorylation of multiple serine and threonine …
[HTML][HTML] The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells
Mutant TP53 proteins are thought to drive the development and sustained expansion of
cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive …
cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive …
p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells
We have previously discovered the naturally occurring antitussive alkaloid noscapine as a
tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at …
tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at …
Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines
Y Hoki, A Fujimori, Y Pommier - Cancer chemotherapy and pharmacology, 1997 - Springer
Camptothecin and its derivatives are specific inhibitors of eukaryotic topoisomerase I (top1)
and are active in cancer patients against a variety of refractory solid tumors and leukemia …
and are active in cancer patients against a variety of refractory solid tumors and leukemia …
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by …
Camptothecins (CPT) activate S or G2-M arrest and the homologous recombination (HR)
repair pathway in tumor cells. In this process, both checkpoint kinases 1 and 2 (Chk1 and …
repair pathway in tumor cells. In this process, both checkpoint kinases 1 and 2 (Chk1 and …
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival
LM Karnitz, KS Flatten, JM Wagner, D Loegering… - Molecular …, 2005 - ASPET
Two signaling pathways are activated by antineoplastic therapies that damage DNA and
stall replication. In one pathway, double-strand breaks activate ataxia-telangiectasia …
stall replication. In one pathway, double-strand breaks activate ataxia-telangiectasia …
Camptothecin analogues with enhanced antitumor activity at acidic pH
DJ Adams, MW Dewhirst, JL Flowers… - Cancer chemotherapy …, 2000 - Springer
Background: Camptothecin (CPT) is a specific inhibitor of the nuclear enzyme
topoisomerase I, which is involved in cellular DNA replication and transcription …
topoisomerase I, which is involved in cellular DNA replication and transcription …
CPT‐11 in human colon‐cancer cell lines and xenografts: characterization of cellular sensitivity determinants
WJM Jansen, B Zwart, STM Hulscher… - … journal of cancer, 1997 - Wiley Online Library
CPT‐11, a new semisynthetic derivative of camptothecin, is active in a number of tumor
types in the clinic, including colon cancer. CPT‐11 is a drug that is converted into the active …
types in the clinic, including colon cancer. CPT‐11 is a drug that is converted into the active …
[引用][C] Preclinical and phase I clinical studies with Ckd‐602, a novel camptothecin derivative
YOUNG-KYUN KIM, NA-YOUN KOO and PIL-YOUNG YUN, Anticancer effects of CKD-602
(Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines, Oncology …
(Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines, Oncology …
Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy
The activation of p53 has been proposed as a novel anti-cancer treatment in two distinct
contexts. In the first activation of p53 in tumor cells can promote apoptosis and senescence …
contexts. In the first activation of p53 in tumor cells can promote apoptosis and senescence …