Psychological stress is known to induce somatic symptoms. Classically, many gut
physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis …

Long-term exposure to adverse life events that provoke acute or chronic psychological
stress (hereinafter “stress”) can negatively affect physical health and even increase …

The interaction between gut inflammatory processes and stress is gaining increasing
recognition. Corticotropin-releasing factor (CRF)-receptor activation in the brain is well …

Psychological stress has long been reported anecdotally to increase disease activity in
inflammatory bowel disease (IBD), and recent well designed studies have confirmed that …

It is well established that central corticotropin releasing factor (CRF) signaling mediates the
gastrointestinal responses to stress. However, as shown in the brain, both CRF receptors …

Stress was characterized by Hans Selye, in 1936, as the “stereotyped biological response to
any demand.” Corticotrophin-releasing factor (CRF) and its related peptides urocortins …

Stress, which is defined as an acute threat to homeostasis, shows both short-and long-term
effects on the functions of the gastrointestinal tract. Exposure to stress results in alterations of …

Stress affects the gastrointestinal tract as part of the visceral response. Various stressors
induce similar profiles of gut motor function alterations, including inhibition of gastric …

There is a functional communication between the gastro-intestinal (GI) and central nervous
system. This communication is bidirectional and it involves anatomic connections like the …

Stress has long been postulated to influence the progression of inflammatory bowel disease
(IBD). Our current understanding of the relationship between stress and IBD is still limited …