The neural tube is an important model system of morphogenesis representing the
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of …

Neural tube defects arise from mechanical failures in the process of neurulation. At the most
fundamental level, formation of the neural tube relies on coordinated, complex tissue …

The vertebrate brain and spinal cord arise from a common precursor, the neural tube, which
forms very early during embryonic development. To shape the forming neural tube, changes …

Neural tube closure is an important and necessary process during the development of the
central nervous system. The formation of the neural tube structure from a flat sheet of neural …

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-
dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular …

Cell division, movement and differentiation contribute to pattern formation in developing
tissues. This is the case in the vertebrate neural tube, in which neurons differentiate in a …

Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

During early development of the central nervous system, the neuroepithelial cells undergo
dynamic changes in shape, cumulative action of which cause the neural plate to bend …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

Vertebrate neural tube closure is associated with complex changes in cell shape and
behavior, however, the relative contribution of these processes to tissue folding is not well …