Tumour development and progression are associated to a variety of events responsible for
normal cell transformation, resulting in uncontrolled cell proliferation, tumour core formation …

In mammalian cells, endoplasmic reticulum (ER) stress has recently been shown to induce
autophagy and the induction requires the unfolded protein response (UPR) signaling …

Background The endoplasmic-reticulum (ER) responds to the burden of unfolded proteins in
its lumen by activating intracellular signal transduction pathways, also known as the …

Outer membrane vesicles (OMVs) are nanometer-sized membrane blebs secreted by all
Gram-negative bacteria to facilitate bacterial communication and modulate the external …

Background: Alveolar epithelial cell death plays a critical role in the pathogenesis of
lipopolysaccharide (LPS)-induced acute lung injury. Increased autophagy has a dual effect …

The importance of autophagy in parasites with a digenetic life cycle like Leishmania spp. is
significant. The parasite survives as promastigotes in the insect gut and as immotile …

Owing to multiple antibiotic resistance, Pseudomonas aeruginosa causes the most
intractable infections to human beings worldwide, thus exploring novel drugs to defend …

Cells exposed to ER-stress undergo the Unfolded Protein Response (UPR) to avoid
apoptosis, but may also activate autophagy. However, the signal for selection of one of these …

Pseudomonas aeruginosa is an opportunistic pathogen that causes life-threatening
infections in cystic fibrosis patients and immunocompromised individuals. A tightly regulated …

The unfolded protein response (UPR) is a cascade of events that helps restoring cellular
homeostasis under stressful conditions. It is activated when there is an imbalance in the …